Assessment for Metabolic Disorders

 

If a metabolic disorder is suspected, The DAN (Defeat Autism Now!) protocol may be used to pinpoint it. Tests for possible metabolic deficits are outlined in the report entitled Clinical Assessment Options For Children With Autism And Related Disorders. This report emanated from a conference of Autism professionals (the Defeat Autism Now! conference) in January 1995. This report is written as a guide for doctors and parents seeking to narrow down the specific metabolic errors in their autistic children. This report is available from the Autism Research Institute in San Diego, California.The tests in these protocols include the following:

  • Urinary Peptides
  • Organic Acids
  • Gluten Sensitivity
  • Stool Analysis
  • Bowel Permeability
  • Secretory lgA
  • Liver detoxification
  • Amino Acid Analysis
  • Folic Acid/Methylmalonic Acid
  • Minerals
  • Erythrocyte Glutathione Peroxidase Activity
  • Food Allergies
  • Immunological Tests
  • Genetic Tests

Laboratory examinations

1. Blood tests:

  • Whole blood: serotonin -chromosomal culture [g-banded chromosomes, Fragile- X by DNA probe]
  • Serum: phenylalaline, pyruvic acid, lactic acid, herpes, cytomegalovirus titres
  • Red blood cell magnesium

2. Twenty-four hour urine for:

  • uric acid
  • organic acids
  • calcium and phosphorus
  • magnesium
  • Homovanillic acid (HVA)
  • creatinine (to check adequacy of 24-hour urine and for calculation of ratios)

3. Cerebrospinal fluid:

  • protein electrophoresis to rule out progressive encephalopathy. 

4. Other laboratory tests:

  • Opthomological examination
  • Auditory examination, include brainstem AEP if child is language delayed
  • EEG [where indicated]
  • MRI [where indicated]

5. Evaluation for abnormal reflexes:

  • Snout reflex – primitive reflex in infants, an involuntary pouting elicited by tapping the center of the closed lips.
  • Visual routing reflex – another primitive reflex, an involuntary rooting in response to the sight of food.
  • Milkmaid sign – a sign of underlying basal ganglia disease; the examiner “milks” the finger of the patient as if milking a cow; the sign is positive if the finger tremors.

 

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http://childrenclinic.wordpress.com/

 

 

Clinical and Editor in Chief :

DR WIDODO JUDARWANTO

email : judarwanto@gmail.com

 

 

 

 

 

 

 

Copyright © 2009, Clinic For Children Information Education Network. All rights reserved.

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